Coriolus Super strength

(PROTEIN-BOUND POLYSACCHARIDE)
Over 300 studies have been conducted and published on the immune supporting* Properties of the 1-4, 1-3. 1-6 linked proteoglycans extracted from the cell walls of Coriolus versicolor including 24 human clinical studies (14 placebo controlled, double-blind, human clinical trials). With Japanese sales exceeding $350 million annually, the cell-wall extract of Coriolus versicolor has become one of the most widely used supplements in the world for addressing immune health.* Decoctions of Coriolus versicolor have been used for centuries in Traditional Chinese Medicine (TCM), with references in the Chinese Compendium of Materia Medica dating as far back as the 15th century. The Ming Dynasty edition states that, "The black and green Yun zhi are beneficial to one's spirit and vital energy, and strengthen one's tendon and bone."

How Supplied

150 Vcaps
400mg per Vcap

Instructions For Use

One to four capsules two times daily, AM and PM, 0n an empty stomach.

Indications

Tonic Immune Support, Serious Immune Challenges, Hepatic Issues.

Toxicity, cautions, Contradictions

Coriolus polysaccharide-peptides are safe and non-toxic, having been used daily in clinical studies lasting five to ten years. However, immuno-modulating substances should be avoided completely in organ-transplant patients or people utilizing immuno-suppressive agents.

Clinical Research

The research shows that the polysaccharide portion of the extract enhances the cell-mediated immune response,* The 1-4, 1-3, 1-6 proteoglycans act as a biological response modifier and have been found to support and enhance Natural Killer cell function, to stimulate depressed lymphocyte proliferation, and to support the healthy growth of white blood cells.*123 The research also shows these constituents to be effective at supporting normal cell growth, improving cell mediated cytotoxicity, and increasing interleukin-2 production and T-cell proliferation*456

Selected Clinical Studies

The results of an eight-year human clinical study, published in 1990, recorded substantial benefit from the daily use of the Coriolus 1-4, 1-3, 1-6 extract. The group receiving the Coriolus extract experienced significant improvements in immune health* as compared to the group receiving the placebo, with the leukocyte activity of the Coriolus group showing "remarkable enhancement." it was concluded that "the beneficial effects were probably do to the activation of leukocyte function* as one of the many bio-logical-response-modifying activities induced by (Coriolus)."7 In a study published in Lancet, Coriolus was found to have a "restorative effect in patients who have been immuno-suppressed."8

Traditional Use And Preparation

Coriolus is sweet in taste and slightly warm in nature, acting through the spleen and heart meridians. It dispels damp and reduces phlegm.9 In TCM, Coriolus is prepared as hot-water extraction/decoction.10 Coriolus is never used in the un-extracted form or prepared as an alcohol tincture.

Active Constituents

Heavy Molecular Weight Polysaccharides ( 1-4,1-3 proteoglycans)

Extraction Information

Hot-water extracts from both the fruit body and the mycelium are used in current clinical practice and research. The active constituents, the polysaccharides, are found in the cell walls of both, although extracts from the fruit body have shown higher levels of immune activity* with oral use.11 Coriolus "Super Strength" is isolated through a multi-step hot-water extraction process, creating a high concentration of the 1-4,1-3 cell-wall constituents used in the Japanese research. As these compounds are difficult to extract and easily degraded with excessive heat NMR and linkage analysis are used to ensure product quality.

References

1. Ooi, V.E., Lui F., Immuno-modulation and anti-cancer activity of polysaccaride-protein complexes. Curr Med chem 2000 Jul;7(7):715-29.
2. Fujui, T.et al. Effect of PSK on prohibited immunity of splenectomized mice. Anticancer Res 1987 Jul-Aug 7(48):845-8.
3. Kobayashi, H et al., PSK as a chemopreventative agent. Cancer Epidemiol Biomakers{ rev 1993 May-Jun; 2(3):271-6.
4. Tsukagoshi, S., et al., Krestin (PSK) Cancer Treat Rev 1984 Jun; 11(2):131-55.
5. Kobayashi, H, et al., Antimetastic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview. Cancer Epidemiol Biomarkers Prev 1995 Apr-May 4(3):275-81.
6. Kanoh, T., et al., Enhancement of teh antitumor effect by the concurrent use of a monoclonal antibody and the protein-bound polysaccahrides PSK in mice bearing a human cancer cell line. in Vivo 1994 Mar-Apr;8(2):241-5.
7. Torisu, M., et al., Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) adminstration after curative surgical operation of colon cancer. Cancer Immunology Immunotherapy. 1990;31:261-268.
8. Nakazato, H et al., Efficacy of immunochemo-therapy as adjuvant treatment after curative resection of gastric cancer Lancet, 343-1122-1126.1994.
9. Hobbs, C., Medicinal Mushrooms, Botanica Press 1995.
10. Lui, b., Bau, Y., Fungi Pharmacopeia. Kiniko Press, 1980.
11Hotta,et al., US Patent #4,271,151.1981.